Pemigatinib is an inhibitor of FGFR that’s used to treat cholangiocarcinoma when there’s an FGFR2 fusion. It does its job by stopping the FGFR signals from getting through. You can get it in three different strengths: 4.5mg, 9mg, or 13.5mg tablets.
The usual dose is 13.5mg, taken every day for a two-week stretch. That’s one 21-day cycle. The tablets come in bottles that have 14 pills in each one.
Pemigatinib is designed to hit cancers with this FGFR2 fusion thing, which is a well-known wonky gene in cholangiocarcinoma. This med’s all about putting a halt to cancer cell growth and spread by tweaking those FGFR signals. Most patients go through the treatment in cycles: 14 days of taking the pill, then a 7-day break to keep side effects to a minimum.
Since it’s an inhibitor, it might shrink tumors, help with symptoms, and even help people live longer if used the right way. Pemigatinib is a pill you take by mouth, just like the doc tells you to. Patients gotta stay on the dose their doc prescribes and keep an eye out for any problems.
You got to check in with your doc regularly to make sure the treatment is going okay and tweak the dose if needed. Pemigatinib’s worked for people with cholangiocarcinoma and FGFR2 fusions, and it’s helped a lot, as shown in all the trials.
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