Alpelisib is an inhibitor of the PI3K enzyme, specifically targeting PI3Kα isoform, which is crucial in HR /HER2breast cancer with PIK3CA mutations. You take it as a film-coated tablet, which comes in three doses: 50 mg, 200 mg, and 300 mg. For adults, the go-to dose is 300 mg, taken once every day with a meal.
These tablets come in blister packs with 28 tabs each. This treatment’s all about zeroing in on the PI3K signaling path, which is kind of a big deal for cancer cells—like, it’s all about cell growth and hanging around when they shouldn’t. This drug is for folks with advanced breast cancer who’ve tried other stuff that didn’t cut it or isn’t working anymore.
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