Gilteritinib is an FLT3 inhibitor. It’s used to treat AML that comes back or doesn’t respond to other treatments, especially when there are FLT3 mutations. It does this by stopping something called FLT3 kinase, which then slows down the growth of the cancer cells.
You get it as 40 mg tablets. The usual amount to take is 120 mg, once a day, on the tongue. The tablets come in bottles with 90 in each.
It works by stopping a protein called FLT3 kinase. This protein is often more active in people with a certain type of AML, called FLT3 internal tandem duplication (ITD) mutations. Gilteritinib hooks onto a part of FLT3 and keeps it from signaling, which stops the cancer cells from growing, moving around, and staying alive.
You can take the tablets with or without food. You keep taking them until the cancer gets worse or something bad happens that’s thought to be caused by the treatment. Checking your blood counts and looking out for bad side effects is a big part of dealing with gilteritinib.
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