So, momelotinib is this inhibitor that goes after JAK1 and JAK2, these really important parts of the JAK/STAT pathway. This pathway is all about causing myelofibrosis and anemia. It’s meant to shrink that big spleen, get rid of the anemia, and calm down the inflammation that comes with those issues.
Momelotinib comes as a tablet you swallow. There are two strengths, 100 mg and 200 mg. For people with myelofibrosis and anemia, the usual dose is 200 mg, and you take it just once a day.
Each bottle holds 30 tablets. This stuff really works to make your spleen smaller and help with the inflammation. It’s all about dealing with those myelofibrosis symptoms better.
You’ll need to keep an eye on your blood and liver stuff to manage the side effects and see how it’s doing. Possible side effects could be feeling tired, having the runs, or stomachaches.
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